Publications

• Own, J., Ulevitch, J., McKay, D. CD14 blockade to prevent ischemic injury to donor organs, Transpl Immunol. 2022 Jun;72:101580. .PMID: 35283329

• DeWolf SE, Kurian S., Kasimsetty SG, Hawkes, AA, Stocks, LM, McKay DB. DAMPs Released from Injured Renal Tubular Epithelial Cells Activate Innate Immune Signals in Healthy Renal Tubular Epithelial Cells, Transplantation. 2021 Dec 23:10.1097. PMID: 34954736

• Kasimsetty S, Hawkes A, DeWolf SE, Welch A, McKay, DB. Blockade of T cell activation induced by the simultaneous absence of Nod1 and Nod2 is bypassed by TLR2 signals . Transpl Immunol. 2021 Apr;65:101348. PMID: 33706865

• Danovitch GM, Bunnapradist S, Cohen D, Hariharan S, McKay D, Ratner L, Stegall MD, Steiner RW, Stock PG, Vincenti F. Tests for the noninvasive diagnosis of kidney transplant rejection should be evaluated by kidney transplant programs. Am J Transplant. 2021 Nov;21(11):3811. PMID: 34080294

• Soo E, Welch A, Marsh C, McKay DB. Molecular strategies used by hibernators: potential therapeutic directions for ischemia reperfusion injury and preservation of human donor organs. Transplant Rev (Orlando). 2020 Jan;34(1):100512. PMID: 31648853

• Soo E, Marsh C, Steiner R, Stocks L, McKay DB. Optimizing organs for transplantation; advancements in perfusion and preservation methods, Transplant Rev (Orlando). 2020 Jan;34(1):100514. PMID: 31645271

• Kasmisetty SG, Hawkes A, Barekatain K, Soo E, Welch AJ, McKay DB. TLR2 and NODs 1 and 2 cooperate in inflammatory responses associated with renal ischemia reperfusion injury, Transpl Immunol. 2020 Feb;58:101260. PMID: 31760144

• Zuk A, Palevsky PM, Fried L, Harrell FE, Khan S, McKay DB, Devey L, Chawla L, de Caestecker M, Kaufman J, B. Thompson T, Agarwal A, Greene T, Okusa M, Bonventre JV, Dember LM, Liu KD, Humphreys BD, Gossett D, Xie Y, Norton JM, Kimmel PL, and Star RA. Acute Kidney Injury Outcomes: Overcoming Barriers in Acute Kidney Injury — A Report from an NIDDK Workshop. CJASN, 2018 6;13(7):1113-1123 PMID: 29523680

• Webster P, Lightstone L, McKay DB, Josephson MA. Pregnancy in chronic kidney disease and kidney transplantation. 2017, Kidney International, May;91(5):1047-1056. PMID: 28209334.78. Martinic M, Caminschi I, O’Keefe M, Thinnes T, Grumont R, Gerondakis S, McKay D, Nemazee D, Gavin A. The bacterial peptidoglycan-sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection. Journal of Immunol, Feb 2017. Apr 1;198(7):2649-2660. PMID:28202617

• Dutt B, Gonzales J, Boyett M, Costanzo A, Han, Peggy P, Steinberg S, McKay DB, Jameson J. mTOR Inhibition by everolimus does not impair closure of punch biopsy wounds in renal transplant patients. Transplantation Direct: Mar 17;3(4):e147. PMID:28405603

• Momper, JD, Misel, ML, McKay, DB. Sex Differences in Pharmacokinetics of Medications Commonly Used in Solid Organ Transplant Recipients, 2017, Transplant Rev Feb 20, PMID:28262425

• DeWolf, SE, Shigeoka, AA, Scheinok, A, Kasimsetty, SG, Welch AK McKay, DB. Expression of TLR2, NOD1 and NOD2 and the NLRP3 inflammasome in renal tubular epithelial cells of male versus female mice, Nephron. 2017;137(1):68-76. PMID:28614830

• Kasimsetty SG, Shigeoka AA, Scheinok AT, Gavin AL, Ulevitch RJ, McKay DB. Lack of Both Nucleotide-Binding Oligomerization Domain-Containing Proteins 1 and 2 Primes T Cells for Activation-Induced Cell Death. J Immunol. 2017 Aug 1;199(3):1196-1205. PMID:28652394

• Ix J, Katz R, Bansal N, Foster M, Weiner D, Tracy R, Jotwani, J, Hughes-Austin J, McKay D, Gabbai F, Hsu C, Bostom A, Levey A, Shlipak M. Urine Fibrosis Markers and Risk of Allograft Failure in Kidney Transplant Recipients: The FAVORIT Trial, Am J Kidney Dis. 2017 Mar;69(3):410-419. PMID:28024930

• Rabb H, Griffin MD, McKay DB, Swaminathan S, Pickkers P, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative Consensus XIII Work Group. Inflammation in AKI: current understanding, key questions and knowledge gaps, JASN 2016, Feb;27(2):371-9; PMID 26561643

• Humphreys BD, Cantaluppi V, Portilla D, Singbartl K, Yang L, Rosner MH, Kellum JA, Ronco C, (ADQI) XIII Work Group. Targeting Endogenous Repair Pathways after AKI. Acute Dialysis Quality Initiative Am Soc Nephrol. 2016 Apr;27(4):990-8. PMID: 26582401

• Basile DP, Bonventre JV, Mehta R, Nangaku M, Unwin R, Rosner MH, Kellum JA, Ronco C; ADQI XIII Work Group. Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments. J Am Soc Nephrol. 2016 Mar;27(3):687-97. PMID: 26519085

• Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, Ronco C; ADQI XIII Work Group. Renal Hemodynamics in AKI: In Search of New Treatment Targets. J Am Soc Nephrol. 2016 Jan;27(1):49-58. PMID: 26510884

• Okusa MD, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative XIII Workgroup. Therapeutic Targets of Human AKI: Harmonizing Human and Animal AKI.

.J Am Soc Nephrol. 2016 Jan;27(1):44-8. PMID: 26519086

• Kasimsetty SG and McKay, DB. Ischemia as a factor affecting innate immune responses in kidney transplantation. 2016, Curr Opin Nephrol Hypertens. 2016 Jan;25(1):3-11; PMID 26625866

• Ratigan ED and McKay DB. Exploring principles of hibernation for organ preservation. Transplant Rev. 2016 Jan;30(1):13-19; PMID 26613668

• Elahimehr, R., Scheinok, AT, McKay, DB. Hematopoietic stem cells and solid organ transplantation, Transplant Rev, 2016; Oct 30(4):227-34; PMID: 27553809

• Weir MR, Burgess ED, Cooper JE, Fenves AZ, Goldsmith D, McKay D, Mehrotra A, Mitsnefes MM, Sica DA, Taler SJ. Assessment and management of hypertension in transplant patients. J Am Soc Nephrol. 2015 Jun;26(6):1248-60. PMID: 25653099

• Kasimsetty SG, Scheinok AT, Shigeoka AA, McKay DB. Simultaneous deletion of NOD1 and NOD2 inhibits in vitro alloresponses but does not prevent allograft rejection. Immunobiology. 2015 Nov;220(11):1227-31 PMID:26159289

• Kasimsetty SG, DeWolf SE, Shigeoka AA, McKay DB. Regulation of TLR2 and NLRP3 in primary murine renal tubular epithelial cells, Nephron Clin Pract 2014;127(1-4):119-23; PMID: 25343834

• Cheung KP, Kasimsetty SG, McKay DB. Innate Immunity in Donor Procurement. Curr Opin Organ Transplant. 2013 Apr; 18(2): 154-60. PMID: 23313940

• Josephson MA, McKay DB. Women and transplantation: fertility, sexuality, pregnancy, contraception. Adv Chronic Kidney Dis. 2013 Sep;20(5):433-40. PMID: 23978550

• Bonventre JV, Basile D, Liu KD, McKay D, Molitoris BA, Nath KA, Nickolas TL, Okusa MD, Palevsky PM, Schnellmann R, Rys-Sikora K, Kimmel PL, Star RA; AKI: a path forward. Kidney Research National Dialogue (KRND). Clin J Am Soc Nephrol. 2013 Sep;8(9):1606-8. PMID: 23868899

• Oatt AM, Steinberg S, McKay DB. Insurance Gaps – Bridging Troubled Waters. ASN Kidney News, 2012; 4(9):14

• McKay DB, Jameson JM. Kidney Transplantation and the Aging Immune System, Nat Rev Nephrol. 2012 Nov 13;8(12):700-8. PMID:23147756

• Josephson, MA and McKay, DB. Pregnancy and Kidney Transplantation. Semin Nephrol. 2011 Jan;31(1):100-10. PMID:21266268

• McKay, DB. The role of innate immunity in the donor organ procurement. Seminars in Immunopathology, invited review, Critical Reviews in Immunology 2011;31(4):297-306. PMID: 21424913

• McKay, DB. Intracellular Pattern Recognition Receptors and Renal Ischemia, invited review, 2011;31(4):297-306. PMID:21899512

• McKay, D.B. and Steinberg, S. “Ten Things Not to Do.” Kidney Transplantation: a guide to the care of the kidney transplant patient, Eds. McKay and Steinberg, New York; Springer, 2010.

• McKay, D.B., Parks, K., Perkins, D. “What is transplant immunology and why are grafts rejected?” Kidney Transplantation: a guide to the care of the kidney transplant patient, Eds. McKay and Steinberg, New York; Springer, 2010

• Pavlakis, M. McKay, D.B. “Sexuality and pregnancy before and after kidney transplantation” Kidney Transplantation: a guide to the care of the kidney transplant patient, Eds. McKay and Steinberg, New York; Springer, 2010.

• McKay, D. and Steinberg, S. Kidney Transplantation: a guide to the care of the kidney transplant patient. New York; Springer, 2010.

• Shigeoka, A, Kambo, A, Mathison, J.C., King, A.J., Hall, F.W., King†, Wesley F. da Silva Correia, J., Ulevitch, R.J., McKay, D.B. Nod1 and Nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury, Journal of Immunology, 2010 Mar 1;184(5):2297-304. PMID:20124104

• Shigeoka, AA, Mueller, JL, Kambo, A, Mathison, J.C., King, A.J., Hall, F.W., da Silva Correia, J., Ulevitch, R.J., Hoffman, HM, McKay, D.B. An inflammasome-independent-role for epithelial-expressed Nlrp3 in renal ischemia reperfusion injury. J Immunol. 2010 Nov 15; 185 (10):6277-85. PMID: 20962258

• McKay, DB, Josephson MA. Pregnancy in Renal Transplant Recipients. Dialysis and Transplantation, 2010, 39 (11): 472-475; doi: 10.1002/dat.20511

• Josephson, MA and McKay, DB. Pregnancy in the Renal Transplant Recipient. 2010, Obstet Gynecol Clin North Am. 2010 Jun; 37(2):211-222; PMID: 20685549

• Fine, RN, Becker, Y. De Geest, S. Eisen, H. Ettenger R., Evans, R. Rudlow, D.L., McKay D., Neu, A., Nevins, T. Reyes J. Wray,J. Dobbels, F. Nonadherence consensus conference summary report. American Journal of Transplantation, 2009, Jan; 9 (1): 35-41; PMID: 19133930

• McKay, DB, Josephson MA. Pregnancy after Kidney Transplantation. Clinical Journal of the American Society of Nephrology, 2008, Mar 3, Suppl 2:S117-25; PMID: 18308999

• McKay, DB. Gender-related Health – room for improvement. American Society of Transplantation Newsletter, 2008, Mar/Apr: 5-6.

• McKay, D., Potter, S., Behrend, T., Stella, F. Steinberg, S. Patients seeking alternatives to the long waiting list: a reality faced by transplant physicians. Progress in Transplantation, 2008, Sep;18(3):203-7; doi:10.1177/152692480801800310

• Mills, R, Taylor, K., Podshivalova, K., McKay, D., Jameson, J. Defects in skin gamma delta T cell function contribute to delayed wound repair in rapamycin-treated mice. Journal of Immunology, 2008. Sep 15;181(6):3974-83; PMID: 18768852

• Zambricki, E, Zal, T, Yachi, P, Shigeoka, A, Sprent, J, Gascoigne, N, McKay, D. In vivo anergized T cells form altered immune synapses in vitro, American Journal of Transplantation, 2006, 6(11):2572; PMID: 16952297

• Josephson MA, McKay DB. Considerations in the medical management of pregnancy in transplant recipients. Advances in Chronic Kidney Disease 2007, Apr 14 (2):156-67; PMID: 17395118

• Shigeoka, AA, Holscher TD, King AJ, Hall FW, Kiosses WB, Tobias PS, Mackman N, McKay DB. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and –independent pathways. Journal of Immunology, 2007, May 15:178 (10): 6252-8; PMID: 17475853

• McKay DB. Federal Funding Cuts Threaten the Viability of Transplant Research, American Society of Transplantation Newsletter, 2007, Jan/Feb: 4-5.

• McKay, DB, Adams PL, Bumgardner GL, Davis CL, Fine RN, Krams SM, Martinez OM, Murphy B, Pavlakis M, Tolkoff-Rubin N, Sherman MS, Josephson MA. Reproduction and pregnancy in transplant recipients: current practices. Progress in Transplantation, 2006, Jun; 16(2):127; PMID: 16789701

• McKay, DB, Josephson, MA. Pregnancy and Transplantation, New England Journal of Medicine, 2006. 354:1281-1293; PMID: 16554530

• McKay, DB and Josephson MA. Pregnancy in Recipients of Solid Organ Transplants. New England Journal of Medicine, 2006; 354(25):2726-2727.; PMID: 16790712

• McKay, DB, Shigeoka, A., Zambricki, E., Rubenstein, M., Surh, CD, Sprent, J. Simultaneous deletion of MyD88 and Trif adapter proteins delays rejection of MHC and minor antigen mismatches allografts, European Journal of Immunology, 2006, 36(8):1994; PMID: 16874736

• McKay, DB, Josephson, MA, et al. Reproduction and Transplantation: report on the AST Consensus Conference on Reproductive Issues and Transplantation, American Journal of Transplantation, 2005, Jul; 5(7):1592-9; PMID: 1594361

• Zambricki, E. Shigeoka, A. Kishimoto, H. Sprent, J. Burakoff, S., Carpenter, C., Milford, E. McKay, D. Signaling T-cell survival and death by IL-2 and IL-15. American Journal of Transplantation 2005, Nov 5: 2623-2631; PMID: 16212621

• McKay DM. ATC Meeting Wrap-up. American Society of Transplantation Newsletter, 2005, July/Aug: 1-22.c

• Rubel JR, Milford EL, McKay DB, Jarcho JA. Renal insufficiency and end-stage renal disease in the heart transplant population. Journal of Heart and Lung Transplantation 2004, Mar;23(3):289-300; PMID: 15019638c

• McKay, DB and King AJ. Donor and recipient issues in renal transplantation. In: The Kidney, 7th edition. 2003. Eds. Brenner, BM, W.B. Saunders, Philadelphia.

• Tkaczuk J., Milford El., Yu C-L., Bakash S., Carpenter CB., Burakoff SJ., McKay DB. Effect of anti-IL-2R alpha antibody on IL-2 induced Jak/STAT signaling. Am J Transplant. 2002 Jan 2:31-40; PMID: 12095053

• Halamay, K.E., Kirkman, R.L., Sun, L. Yamada, A., Fragoso, R.C., Shimizu, K.

Mitchell, R.N., McKay, D.B. CD8 T Cells are Sufficient to Mediate Allorecognition and Allograft Rejection, Cellular Immunology 2002, Mar;216(1-2):6-14; PMID: 12381345

• Tkaczuk J., Milford El., Yu C-L., Bakash S., Carpenter CB., Burakoff SJ., McKay DB. Intracellular signaling consequences of anti-IL-2Ralpha blockade by daclizumab, 2001, Transplant Proc, 33:212-213; PMID: 11266783

• Tran HTB, Acharya MK, McKay DB, Sayegh MH, Carpenter CB, Auchincloss H, Kirkman RL, Milford EL. Avoidance of cyclosporine in renal transplantation: effects of daclizumab, mycophenolate mofetil and steroids. 2000, Journal of the American Society of Nephrology, 11:1903-1090; PMID: 11004222

• McKay DB. Immunologic complications of transplantation. The Kidney; Transplant/Dialysis. 2000. Eds. Faber, RL, Wilde, SW. KTDA, Boston, MA.

• McKay DB and Burakoff SJ. Biochemical Basis of Allograft Tolerance. 2000, Graft, May;3:20-25.

• McKay DB, Irie HY, Hollander G, Ferrara JLM, Strom TS, Li YS, Burakoff SJ. Antigen-induced unresponsiveness results in altered T cell receptor signals. 1999, Journal of Immunology, Dec 15;163:6455-6461; PMID: 10586036

• McKay DB, Milford, EL, Tolkoff-Rubin. Clinical Renal Transplantation. In: The Kidney, 6th edition. 1999. Eds. Brenner, BM, W.B. Saunders, Philadelphia.

• McKay DB and Milford, EL. Evaluation of Renal Transplant Candidates and Donors. In: Dialysis and Transplantation: A Companion to Brenner and Rector's 'The Kidney'. 1999 Eds Owen W, Pereira BJ, Sayegh M., W.B. Saunders, Philadelphia.

• Natov SN, Lau JY, Bouthot BA, Murthy BV, Ruthazer R, Schmid CH, Levey AS, Pereira BJ and the New England Organ Hepatitis Study Group (Kirkman RL; Pereira BJG; Levey AS; Lorber MI; Leeber DA; Shapiro ME; Milford EL; McKay DB; Harmon, WE; Dienstag JL). Serologic and virologic profiles of hepatitis C infection in renal transplant candidates. Am J Kidney Dis 1998; 31(6):920-927; PMID 9631834

• Pereira BJ, Natov, SN, Bouthot BA, Murthy BV, Ruthazer R, Schmid CH, Levey AS and the New England Organ Hepatitis Study Group (Kirkman RL; Pereira BJG; Levey AS; Lorber MI; Leeber DA; Shapiro ME; Milford EL; McKay DB; Harmon, WE; Dienstag JL). Effects of hepatitis C infection and renal transplantation on survival in end-stage renal disease. Kidney Int. 1998 53(5):1374-1381; PMID: 9573555

• McKay DB, Carpenter CB, Churchill WH, Axelrod JD, Milford EL, Aranki SF, Adams DH, Couper GS, Mudge GH. Induction of specific tolerance by HLA alloantigens. Blood Purification 1996 14:103; DOI:10.1159/000316906

• McKay DB, Milford, EL, Sayegh MH. Clinical Renal Transplantation. In: The Kidney, 5th edition. Eds. Brenner, BM, Rector, FC, W.B. Saunders, Philadelphia, 1995.

• Pereira BJ, Wright TL, Schmid CH, Levey AS and the New England Organ Hepatitis Study Group (Kirkman RL; Pereira BJG; Levey AS; Lorber MI; Leeber DA; Shapiro ME; Milford EL; McKay DB; Harmon, WE; Dienstag JL). A controlled study of hepatitis C transmission by organ transplantation. Lancet 1995; 345 (8948):484-7; PMID: 7532254

• McKay DB, Milford EL, Carpenter CB, Kartashov AI, Schoen FJ, Loh E, Aranki AF, Couper GS, Mudge GH. T cell activation in cardiac transplant recipients. Transplantation 1994; 58(2):241-245; PMID: 8042242

• McKay DB, Vasquez VA, Redline RW, Lu CY. Macrophage functions are regulated by murine decidual and tumor extracellular matrices. J Clin Invest 1992; 89(1):134-147; PMID 1729266

• Kirkman RL, Shapiro ME, Carpenter CB, McKay DB, Milford EL, Ramos EL, Tilney NL, Waldmann TA, Zimmerman CE, Strom TE. A randomized prospective trial of anti-TAC monoclonal antibody in human renal transplantation. Transplantation 1991; 51(1):107-113; PMID 1846250

• McKay DB, Lu CY. Listeriolysin as a virulence factor in Listeria monocytogenes infection of neonatal mice and murine decidual tissue. Infect Immun 1991; 59(11):4286-4290; PMID 1937789

• McKay DB. Anti-interleukin-2 receptor antibody (33B3.1) to prevent renal transplant rejection. Perspectives in Hypertension and Renal Disease. 1991; 4 (1):10-11.

• McKay DB. A national kidney-sharing system based on HLA matching. Perspectives in Hypertension and Renal Disease. 1991; 4 (3):6-7.

• McKay DB. Importance of HLA-DR matching to allograft survival. Perspectives in Hypertension and Renal Disease. 1991; 4 (2):6-7.

• Lu CY, Redline RW, McKay DB, Dustin LB, Shea CM. Inhibition of macrophage and T-lymphocyte functions in the placenta and decidua during listeriosis: Implications for tolerance of the fetoplacental allograft; in Molecular and Cellular Immunobiology of the Maternal Fetal Interface. 1991; Ed. Wegmann, Gill, Brown, ISBN: 019506304X

• Redline RW, McKay DB, Vasquez VA, Papaioannou VE, Lu CY. Macrophage functions are regulated by the substratum of murine decidual stromal cells. J Clin Invest 1990; 85(6):1951-1958; PMID 2347918

• Esparza AR, McKay DB, Cronan JJ, Chazan JA. Renal parenchymal malakoplakia. Histologic spectrum and its relationship to megalocytic interstitial nephritis and xanthogranulomatous pyelonephritis. Am J Surg Pathol 1989; 13(3):225-236; PMID: 2919720

• McKay D, Chazan JA. Acid-base abnormalities in cardiopulmonary arrest. J Intensive Care Med 1989; 4:243-247; doi:10.1177/088506668900400602

• Lu CY, Redline RW, Shea CM, Dustin LB, McKay DB. Pregnancy as a natural model of allograft tolerance. Interactions between adherent macrophages and trophoblast populations. Transplantation 1989; 48(5):848-855; PMID 2573182

• Lu CY, Redline RW, McKay DB, Dustin LB, Shea CM. Regulation of Macrophage Functions in the Murine Placenta and Decidua: Implications for Maternal Tolerance of the Fetal Allograft. Transplant Revs 1989 (3):195-214; http://dx.doi.org/10.1016/S0955-470X(89)80013-8

• Chazan JA, McKay DB. Acid-base abnormalities in cardiopulmonary arrest: Varying patterns in different locations in the hospital New Engl J Med 1989; 320:597-598; PMID 2915672

• Witt D, McKay D, Schwam L., Goldstein D, Gold J. Acquired immune deficiency syndrome presenting as bone marrow and mediastinal cryptococcosis. Am J Med 1987; 82(1):149-50; PMID:3799674